[Dmt1]DALDA analogues modified with tyrosine analogues at position 1
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چکیده
منابع مشابه
Strigolactone Analogues with a D‐Ring Modified at C‐2
Strigolactones (SLs) are important new plant hormones that receive much attention in current plant science. SLs are produced by many plants and are exuded by the root system. SLs are, amongst others, germination stimulants for seed of parasitic weeds. Naturally occurring SLs invariably contain three annelated rings, the ABC-scaffold, connected to a butenolide (the D-ring) via an enol ether unit...
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Starting from cinnamates 9, obtained by Wittig reaction or Heck coupling, the diols 17 were prepared by asymmetric dihydroxylation. This was followed by a regioselective substitution of the 3-OH group with hydrazoic acid under Mitsunobu conditions. Methylation of the 2-OH group and reduction of the azide group led to the β-tyrosine derivatives 8. Condensation with the dipeptide acid 6 furnished...
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Cyclodepsipeptides comprise a unique class of secondary metabolides. They frequently contain unusual amino acids, like d-amino acids or N-methylated amino acids and hydroxy acids that typically originate from the polyketide pathway. Incorporation of the hydroxy acid results in an ester bond, explaining the term “depsi”. Many cyclodepsipeptides have been isolated from marine sponges and found to...
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ATP has long been known to play a central role in the energetics of cells both in transduction mechanisms and in metabolic pathways, and is involved in regulation of enzyme, channel and receptor activities. Numerous ATP analogues have been synthesised to probe the role of ATP in biosystems (Yount, 1975; Jameson and Eccleston, 1997; Bagshaw, 1998). In general, two contrasting strategies are empl...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2016
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2016.06.003